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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E
All Species:
43.03
Human Site:
S146
Identified Species:
59.17
UniProt:
P06730
Number Species:
16
Phosphosite Substitution
Charge Score:
0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06730
NP_001959.1
217
25097
S146
G
E
S
F
D
D
Y
S
D
D
V
C
G
A
V
Chimpanzee
Pan troglodytes
XP_523824
217
24938
S146
G
E
S
F
D
D
Y
S
D
D
V
C
G
A
V
Rhesus Macaque
Macaca mulatta
XP_001092045
253
28850
S182
G
E
S
F
E
E
H
S
R
E
V
C
G
A
V
Dog
Lupus familis
XP_544992
217
25075
S146
G
E
S
F
D
D
Y
S
D
D
V
C
G
A
V
Cat
Felis silvestris
Mouse
Mus musculus
Q3UTA9
244
27967
S174
G
N
C
F
E
E
Y
S
R
E
V
C
G
A
V
Rat
Rattus norvegicus
P63074
217
25035
S146
G
E
S
F
D
D
Y
S
D
D
V
C
G
A
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514651
236
27161
E161
I
E
P
M
W
E
D
E
K
N
K
R
G
G
R
Chicken
Gallus gallus
XP_420655
217
25026
S146
G
E
S
F
D
D
Y
S
D
D
V
C
G
A
V
Frog
Xenopus laevis
P48597
213
24616
S142
G
E
S
F
D
E
H
S
D
D
V
C
G
A
V
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
S144
G
E
A
F
D
D
H
S
D
D
V
C
G
A
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
D189
G
E
A
F
D
H
S
D
Q
I
C
G
A
V
I
Honey Bee
Apis mellifera
XP_624290
213
24784
S142
G
E
A
F
N
G
Y
S
D
D
I
C
G
A
V
Nematode Worm
Caenorhab. elegans
O61955
248
27791
G141
G
E
Q
F
D
E
Y
G
D
Y
I
C
G
A
V
Sea Urchin
Strong. purpuratus
NP_001091928
225
25645
S154
G
E
S
F
D
D
D
S
D
L
V
N
G
A
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
D151
G
E
Q
F
D
Y
G
D
E
I
C
G
A
V
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23252
235
26501
D168
G
E
Q
F
D
H
G
D
E
I
C
G
A
V
V
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
D146
G
E
T
I
D
E
D
D
S
Q
I
N
G
V
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
59.2
99.5
N.A.
53.2
98.1
N.A.
71.6
92.1
88.4
82.9
N.A.
43.6
54.8
41.1
53.7
Protein Similarity:
100
98.6
69.1
99.5
N.A.
69.2
98.6
N.A.
74.1
94
94
92.6
N.A.
56.3
68.6
58.8
73.7
P-Site Identity:
100
100
66.6
100
N.A.
60
100
N.A.
13.3
100
86.6
86.6
N.A.
26.6
73.3
66.6
80
P-Site Similarity:
100
100
93.3
100
N.A.
80
100
N.A.
26.6
100
100
100
N.A.
40
93.3
80
80
Percent
Protein Identity:
N.A.
42.2
N.A.
39.5
31.8
N.A.
Protein Similarity:
N.A.
56.8
N.A.
54
55.3
N.A.
P-Site Identity:
N.A.
33.3
N.A.
33.3
33.3
N.A.
P-Site Similarity:
N.A.
40
N.A.
40
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
18
0
0
0
0
0
0
0
0
0
18
71
0
% A
% Cys:
0
0
6
0
0
0
0
0
0
0
18
65
0
0
0
% C
% Asp:
0
0
0
0
77
42
18
24
59
48
0
0
0
0
0
% D
% Glu:
0
95
0
0
12
36
0
6
12
12
0
0
0
0
0
% E
% Phe:
0
0
0
89
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
95
0
0
0
0
6
12
6
0
0
0
18
83
6
0
% G
% His:
0
0
0
0
0
12
18
0
0
0
0
0
0
0
0
% H
% Ile:
6
0
0
6
0
0
0
0
0
18
18
0
0
0
6
% I
% Lys:
0
0
0
0
0
0
0
0
6
0
6
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
6
0
0
0
0
0
% L
% Met:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
6
0
0
6
0
0
0
0
6
0
12
0
0
0
% N
% Pro:
0
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
18
0
0
0
0
0
6
6
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
12
0
0
6
0
0
6
% R
% Ser:
0
0
48
0
0
0
6
65
6
0
0
0
0
0
0
% S
% Thr:
0
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
59
0
0
24
89
% V
% Trp:
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
6
48
0
0
6
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _